United States securities and exchange commission logo May 2, 2022 Mark Manfredi Chief Executive Officer Ikena Oncology, Inc. 645 Summer Street, Suite 101 Boston, MA 02210 Re: Ikena Oncology, Inc. Registration Statement on Form S-3 Filed April 27, 2022 File No. 333-264517 Dear Dr. Manfredi: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Doris Stacey Gama at 202-551-3188 or Laura Crotty at 202-551-7614 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Stephanie Richards, Esq.